Place top oven rack in the center position and preheat oven to 400°F.
Arrange potato wedges in a single layer in a large cast iron skillet. Sprinkle with garlic powder and season generously with salt and black pepper. Set aside.
Whisk together chicken broth, olive oil, lemon juice, lemon zest, and dried oregano in a medium bowl. Pour mixture over the potatoes, making sure they’re well coated.
Place skillet in preheated oven and cook for 25 minutes. Carefully turn the potatoes and return to oven for another 25 minutes.
Remove skillet from oven and carefully drain and reserve the excess cooking liquid. Return skillet to oven for another 5 minutes, or until potatoes are nicely browned and crispy on the edges.
Remove from oven and let cool slightly. Drizzle some of the reserved cooking liquid over the potatoes before serving. Garnish with fresh oregano if desired. Enjoy!